PRKCA-binding protein (PICK1)
Homo sapiens — UniProt Q9NRD5
Data last refreshed: (UniProt release unknown)
Key facts
PRKCA-binding protein (PICK1) is a protein from Homo sapiens identified by UniProt accession Q9NRD5, 415 residues long. MolForge cross-references it against 0 known binders and 205 disease associations.
- UniProt accession: Q9NRD5; gene symbol PICK1.
- Organism: Homo sapiens.
- Length: 415 amino acids.
- Top disease associations (Open Targets): male infertility due to globozoospermia, neurodegenerative disease and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PRKCA-binding protein |
|---|---|
| UniProt accession | Q9NRD5 |
| Gene | PICK1 |
| Organism | Homo sapiens |
| Length | 415 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (205)
Diseases linked to this target (Open Targets).
- male infertility due to globozoospermia · score 0.38
- neurodegenerative disease · score 0.36
- Parkinson disease · score 0.36
- lysosomal storage disease · score 0.36
- Alzheimer disease · score 0.36
- multiple sclerosis · score 0.36
- neuroinflammatory disorder · score 0.23
- white matter microstructure measurement · score 0.20
- breast adenocarcinoma · score 0.18
- mean platelet volume · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRD5-F1 | alphafold | PREDICTED | 80.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRD5.
Amino-acid sequence (415 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PICK1?
The strongest Open Targets associations for PICK1 are male infertility due to globozoospermia, neurodegenerative disease, Parkinson disease, lysosomal storage disease and Alzheimer disease.
How long is the PICK1 protein?
The Homo sapiens PICK1 protein (UniProt Q9NRD5) is 415 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRD5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRD5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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