Dual oxidase 1 (DUOX1)
Homo sapiens — UniProt Q9NRD9
Data last refreshed: (UniProt release unknown)
Key facts
Dual oxidase 1 (DUOX1) is a protein from Homo sapiens identified by UniProt accession Q9NRD9, 1551 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.
- UniProt accession: Q9NRD9; gene symbol DUOX1.
- Organism: Homo sapiens.
- Length: 1551 amino acids.
- Top disease associations (Open Targets): cortical thickness, brain measurement and creatinine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dual oxidase 1 |
|---|---|
| UniProt accession | Q9NRD9 |
| Gene | DUOX1 |
| Organism | Homo sapiens |
| Length | 1551 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (164)
Diseases linked to this target (Open Targets).
- cortical thickness · score 0.31
- brain measurement · score 0.27
- creatinine measurement · score 0.26
- lung adenocarcinoma · score 0.19
- cutaneous melanoma · score 0.16
- esophageal disease · score 0.09
- neoplasm · score 0.09
- infection · score 0.08
- infect · score 0.08
- chronic obstructive pulmonary disease · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRD9-F1 | alphafold | PREDICTED | 85.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRD9.
Amino-acid sequence (1551 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DUOX1?
The strongest Open Targets associations for DUOX1 are cortical thickness, brain measurement, creatinine measurement, lung adenocarcinoma and cutaneous melanoma.
How long is the DUOX1 protein?
The Homo sapiens DUOX1 protein (UniProt Q9NRD9) is 1551 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRD9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRD9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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