Matrix metalloproteinase-26 (MMP26)

About Matrix metalloproteinase-26

Matrix metalloproteinase-26 (MMP26) is a protein from Homo sapiens identified by UniProt accession Q9NRE1, 261 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Matrix metalloproteinase-26
UniProt accession	Q9NRE1
Gene	MMP26
Organism	Homo sapiens
Length	261 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
Alzheimer disease · score 0.26
lysosomal storage disease · score 0.26
Parkinson disease · score 0.26
multiple sclerosis · score 0.26
bladder exstrophy · score 0.12
myoepithelial tumor · score 0.11
malaria · score 0.10
mean corpuscular volume · score 0.06
hepatocellular carcinoma · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NRE1-F1	alphafold	PREDICTED	79.10	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRE1.

Amino-acid sequence (261 residues)

MQLVILRVTI FLPWCFAVPV PPAADHKGWD FVEGYFHQFF LTKKESPLLT QETQTQLLQQ FHRNGTDLLD MQMHALLHQP HCGVPDGSDT SISPGRCKWN KHTLTYRIIN YPHDMKPSAV KDSIYNAVSI WSNVTPLIFQ QVQNGDADIK VSFWQWAHED GWPFDGPGGI LGHAFLPNSG NPGVVHFDKN EHWSASDTGY NLFLVATHEI GHSLGLQHSG NQSSIMYPTY WYHDPRTFQL SADDIQRIQH LYGEKCSSDI P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards