CTP synthase 2 (CTPS2)
Homo sapiens — UniProt Q9NRF8
Data last refreshed: (UniProt release unknown)
Key facts
CTP synthase 2 (CTPS2) is a protein from Homo sapiens identified by UniProt accession Q9NRF8, 586 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q9NRF8; gene symbol CTPS2.
- Organism: Homo sapiens.
- Length: 586 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, chronic lymphocytic leukemia and 3-hydroxy-1-methylpropylmercapturic acid measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CTP synthase 2 |
|---|---|
| UniProt accession | Q9NRF8 |
| Gene | CTPS2 |
| Organism | Homo sapiens |
| Length | 586 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- chronic lymphocytic leukemia · score 0.07
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.05
- osteosarcoma · score 0.02
- cancer · score 0.01
- oligodendroglioma · score 0.01
- astrocytoma · score 0.01
- T-cell acute lymphoblastic leukemia · score 0.01
- acute lymphoblastic leukemia · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRF8-F1 | alphafold | PREDICTED | 91.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRF8.
Amino-acid sequence (586 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CTPS2?
The strongest Open Targets associations for CTPS2 are neurodegenerative disease, chronic lymphocytic leukemia, 3-hydroxy-1-methylpropylmercapturic acid measurement, osteosarcoma and cancer.
How long is the CTPS2 protein?
The Homo sapiens CTPS2 protein (UniProt Q9NRF8) is 586 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRF8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRF8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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