DNA polymerase epsilon subunit 3 (POLE3)
Homo sapiens — UniProt Q9NRF9
Data last refreshed: (UniProt release unknown)
Key facts
DNA polymerase epsilon subunit 3 (POLE3) is a protein from Homo sapiens identified by UniProt accession Q9NRF9, 147 residues long. MolForge cross-references it against 0 known binders and 410 disease associations.
- UniProt accession: Q9NRF9; gene symbol POLE3.
- Organism: Homo sapiens.
- Length: 147 amino acids.
- Top disease associations (Open Targets): non-small cell lung carcinoma, acute myeloid leukemia and acute lymphoblastic leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA polymerase epsilon subunit 3 |
|---|---|
| UniProt accession | Q9NRF9 |
| Gene | POLE3 |
| Organism | Homo sapiens |
| Length | 147 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (410)
Diseases linked to this target (Open Targets).
- non-small cell lung carcinoma · score 0.60
- acute myeloid leukemia · score 0.60
- acute lymphoblastic leukemia · score 0.60
- pancreatic carcinoma · score 0.59
- chronic lymphocytic leukemia · score 0.59
- ovarian carcinoma · score 0.57
- breast carcinoma · score 0.57
- adult acute lymphoblastic leukemia · score 0.56
- leukemia · score 0.56
- breast cancer · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRF9-F1 | alphafold | PREDICTED | 86.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRF9.
Amino-acid sequence (147 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLE3?
The strongest Open Targets associations for POLE3 are non-small cell lung carcinoma, acute myeloid leukemia, acute lymphoblastic leukemia, pancreatic carcinoma and chronic lymphocytic leukemia.
How long is the POLE3 protein?
The Homo sapiens POLE3 protein (UniProt Q9NRF9) is 147 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRF9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRF9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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