N-lysine methyltransferase SMYD2 (SMYD2)
Homo sapiens — UniProt Q9NRG4
Data last refreshed: (UniProt release unknown)
Key facts
N-lysine methyltransferase SMYD2 (SMYD2) is a protein from Homo sapiens identified by UniProt accession Q9NRG4, 433 residues long. MolForge cross-references it against 0 known binders and 184 disease associations.
- UniProt accession: Q9NRG4; gene symbol SMYD2.
- Organism: Homo sapiens.
- Length: 433 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, lymphocyte count and C-reactive protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-lysine methyltransferase SMYD2 |
|---|---|
| UniProt accession | Q9NRG4 |
| Gene | SMYD2 |
| Organism | Homo sapiens |
| Length | 433 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (184)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.38
- lymphocyte count · score 0.36
- C-reactive protein measurement · score 0.32
- alkaline phosphatase measurement · score 0.30
- breast adenocarcinoma · score 0.27
- age at first sexual intercourse measurement · score 0.25
- glioblastoma multiforme · score 0.25
- smoking status measurement · score 0.24
- attention deficit hyperactivity disorder · score 0.24
- smoking initiation · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRG4-F1 | alphafold | PREDICTED | 97.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRG4.
Amino-acid sequence (433 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMYD2?
The strongest Open Targets associations for SMYD2 are sex hormone-binding globulin measurement, lymphocyte count, C-reactive protein measurement, alkaline phosphatase measurement and breast adenocarcinoma.
How long is the SMYD2 protein?
The Homo sapiens SMYD2 protein (UniProt Q9NRG4) is 433 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRG4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRG4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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