Poly(A) polymerase beta (PAPOLB)
Homo sapiens — UniProt Q9NRJ5
Data last refreshed: (UniProt release unknown)
Key facts
Poly(A) polymerase beta (PAPOLB) is a protein from Homo sapiens identified by UniProt accession Q9NRJ5, 637 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.
- UniProt accession: Q9NRJ5; gene symbol PAPOLB.
- Organism: Homo sapiens.
- Length: 637 amino acids.
- Top disease associations (Open Targets): electrocardiography, azoospermia and partial chromosome Y deletion.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Poly(A) polymerase beta |
|---|---|
| UniProt accession | Q9NRJ5 |
| Gene | PAPOLB |
| Organism | Homo sapiens |
| Length | 637 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (107)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.15
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- spermatogenic failures 50 · score 0.07
- spermatogenic failure 25 · score 0.07
- spermatogenic failure, X-linked, 2 · score 0.07
- spermatogenic failure 63 · score 0.07
- Testicular regression syndrome · score 0.06
- isochromosomy Yp · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRJ5-F1 | alphafold | PREDICTED | 79.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRJ5.
Amino-acid sequence (637 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PAPOLB?
The strongest Open Targets associations for PAPOLB are electrocardiography, azoospermia, partial chromosome Y deletion, male infertility with teratozoospermia due to single gene mutation and spermatogenic failures 50.
How long is the PAPOLB protein?
The Homo sapiens PAPOLB protein (UniProt Q9NRJ5) is 637 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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