Enamelin (ENAM)
Homo sapiens — UniProt Q9NRM1
Data last refreshed: (UniProt release unknown)
Key facts
Enamelin (ENAM) is a protein from Homo sapiens identified by UniProt accession Q9NRM1, 1142 residues long. MolForge cross-references it against 0 known binders and 301 disease associations.
- UniProt accession: Q9NRM1; gene symbol ENAM.
- Organism: Homo sapiens.
- Length: 1142 amino acids.
- Top disease associations (Open Targets): Hypoplastic amelogenesis imperfecta, amelogenesis imperfecta and body fat percentage.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Enamelin |
|---|---|
| UniProt accession | Q9NRM1 |
| Gene | ENAM |
| Organism | Homo sapiens |
| Length | 1142 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (301)
Diseases linked to this target (Open Targets).
- Hypoplastic amelogenesis imperfecta · score 0.67
- amelogenesis imperfecta · score 0.56
- body fat percentage · score 0.26
- genetic disorder · score 0.19
- Hypomaturation amelogenesis imperfecta · score 0.12
- dentin dysplasia type I · score 0.11
- amelogenesis imperfecta type 3B · score 0.11
- amelogenesis imperfecta hypomaturation type 2A4 · score 0.11
- amelogenesis imperfecta, IIa 1K · score 0.11
- amelogenesis imperfecta, type ij · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRM1-F1 | alphafold | PREDICTED | 36.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRM1.
Amino-acid sequence (1142 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ENAM?
The strongest Open Targets associations for ENAM are Hypoplastic amelogenesis imperfecta, amelogenesis imperfecta, body fat percentage, genetic disorder and Hypomaturation amelogenesis imperfecta.
How long is the ENAM protein?
The Homo sapiens ENAM protein (UniProt Q9NRM1) is 1142 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRM1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRM1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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