Zinc finger protein 277 (ZNF277)
Homo sapiens — UniProt Q9NRM2
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 277 (ZNF277) is a protein from Homo sapiens identified by UniProt accession Q9NRM2, 450 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q9NRM2; gene symbol ZNF277.
- Organism: Homo sapiens.
- Length: 450 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, neurodegenerative disease and Young adult-onset Parkinsonism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 277 |
|---|---|
| UniProt accession | Q9NRM2 |
| Gene | ZNF277 |
| Organism | Homo sapiens |
| Length | 450 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.34
- neurodegenerative disease · score 0.32
- Young adult-onset Parkinsonism · score 0.24
- Abnormality of refraction · score 0.15
- protein measurement · score 0.09
- drug use measurement · score 0.08
- sex hormone-binding globulin measurement · score 0.07
- serum albumin measurement · score 0.07
- mathematical ability · score 0.05
- diastolic blood pressure · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRM2-F1 | alphafold | PREDICTED | 73.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRM2.
Amino-acid sequence (450 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF277?
The strongest Open Targets associations for ZNF277 are self reported educational attainment, neurodegenerative disease, Young adult-onset Parkinsonism, Abnormality of refraction and protein measurement.
How long is the ZNF277 protein?
The Homo sapiens ZNF277 protein (UniProt Q9NRM2) is 450 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRM2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRM2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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