Serine/threonine-protein kinase LATS2 (LATS2)
Homo sapiens — UniProt Q9NRM7
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase LATS2 (LATS2) is a protein from Homo sapiens identified by UniProt accession Q9NRM7, 1088 residues long. MolForge cross-references it against 6 known binders and 266 disease associations.
- UniProt accession: Q9NRM7; gene symbol LATS2.
- Organism: Homo sapiens.
- Length: 1088 amino acids.
- Top disease associations (Open Targets): Pleural Mesothelioma, neurodegenerative disease and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase LATS2 |
|---|---|
| UniProt accession | Q9NRM7 |
| Gene | LATS2 |
| Organism | Homo sapiens |
| Length | 1088 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (266)
Diseases linked to this target (Open Targets).
- Pleural Mesothelioma · score 0.57
- neurodegenerative disease · score 0.55
- systolic blood pressure · score 0.46
- body height · score 0.45
- urate measurement · score 0.41
- bone density · score 0.41
- appendicular lean mass · score 0.41
- colorectal adenocarcinoma · score 0.40
- skin basal cell carcinoma · score 0.37
- lymphoid neoplasm · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRM7-F1 | alphafold | PREDICTED | 55.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRM7.
Amino-acid sequence (1088 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LATS2?
The strongest Open Targets associations for LATS2 are Pleural Mesothelioma, neurodegenerative disease, systolic blood pressure, body height and urate measurement.
How long is the LATS2 protein?
The Homo sapiens LATS2 protein (UniProt Q9NRM7) is 1088 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRM7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRM7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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