rRNA N(6)-adenosine-methyltransferase METTL5 (METTL5)
Homo sapiens — UniProt Q9NRN9
Data last refreshed: (UniProt release unknown)
Key facts
rRNA N(6)-adenosine-methyltransferase METTL5 (METTL5) is a protein from Homo sapiens identified by UniProt accession Q9NRN9, 209 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.
- UniProt accession: Q9NRN9; gene symbol METTL5.
- Organism: Homo sapiens.
- Length: 209 amino acids.
- Top disease associations (Open Targets): intellectual developmental disorder, autosomal recessive 72, Intellectual disability, severe and autosomal recessive primary microcephaly.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | rRNA N(6)-adenosine-methyltransferase METTL5 |
|---|---|
| UniProt accession | Q9NRN9 |
| Gene | METTL5 |
| Organism | Homo sapiens |
| Length | 209 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (77)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder, autosomal recessive 72 · score 0.67
- Intellectual disability, severe · score 0.43
- autosomal recessive primary microcephaly · score 0.37
- neurodegenerative disease · score 0.32
- genetic disorder · score 0.18
- hepatocellular carcinoma · score 0.10
- gonorrhea · score 0.09
- neoplasm · score 0.08
- platelet count · score 0.05
- diet measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRN9-F1 | alphafold | PREDICTED | 92.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRN9.
Amino-acid sequence (209 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL5?
The strongest Open Targets associations for METTL5 are intellectual developmental disorder, autosomal recessive 72, Intellectual disability, severe, autosomal recessive primary microcephaly, neurodegenerative disease and genetic disorder.
How long is the METTL5 protein?
The Homo sapiens METTL5 protein (UniProt Q9NRN9) is 209 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRN9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRN9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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