Succinate dehydrogenase assembly factor 3, mitochondrial (SDHAF3)
Homo sapiens — UniProt Q9NRP4
Data last refreshed: (UniProt release unknown)
Key facts
Succinate dehydrogenase assembly factor 3, mitochondrial (SDHAF3) is a protein from Homo sapiens identified by UniProt accession Q9NRP4, 125 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q9NRP4; gene symbol SDHAF3.
- Organism: Homo sapiens.
- Length: 125 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, PHF-tau measurement and Paraganglioma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Succinate dehydrogenase assembly factor 3, mitochondrial |
|---|---|
| UniProt accession | Q9NRP4 |
| Gene | SDHAF3 |
| Organism | Homo sapiens |
| Length | 125 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.38
- PHF-tau measurement · score 0.28
- Paraganglioma · score 0.04
- pachyonychia congenita · score 0.04
- bone density · score 0.04
- bone quantitative ultrasound measurement · score 0.03
- lobe attachment · score 0.03
- chronotype measurement · score 0.03
- adrenal gland pheochromocytoma · score 0.03
- diastolic blood pressure · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRP4-F1 | alphafold | PREDICTED | 88.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRP4.
Amino-acid sequence (125 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SDHAF3?
The strongest Open Targets associations for SDHAF3 are heel bone mineral density, PHF-tau measurement, Paraganglioma, pachyonychia congenita and bone density.
How long is the SDHAF3 protein?
The Homo sapiens SDHAF3 protein (UniProt Q9NRP4) is 125 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRP4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRP4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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