Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4)
Homo sapiens — UniProt Q9NRQ5
Data last refreshed: (UniProt release unknown)
Key facts
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) is a protein from Homo sapiens identified by UniProt accession Q9NRQ5, 59 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q9NRQ5; gene symbol SMCO4.
- Organism: Homo sapiens.
- Length: 59 amino acids.
- Top disease associations (Open Targets): body mass index, serum alanine aminotransferase measurement and multiple gestation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Single-pass membrane and coiled-coil domain-containing protein 4 |
|---|---|
| UniProt accession | Q9NRQ5 |
| Gene | SMCO4 |
| Organism | Homo sapiens |
| Length | 59 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- body mass index · score 0.46
- serum alanine aminotransferase measurement · score 0.32
- multiple gestation · score 0.31
- body height · score 0.29
- mathematical ability · score 0.13
- adolescent idiopathic scoliosis · score 0.03
- type 2 diabetes mellitus · score 0.02
- ovarian carcinoma · score 0.02
- bacteriemia · score 0.01
- neurofibromatosis type 1 · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRQ5-F1 | alphafold | PREDICTED | 74.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRQ5.
Amino-acid sequence (59 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMCO4?
The strongest Open Targets associations for SMCO4 are body mass index, serum alanine aminotransferase measurement, multiple gestation, body height and mathematical ability.
How long is the SMCO4 protein?
The Homo sapiens SMCO4 protein (UniProt Q9NRQ5) is 59 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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