Phosphatidylinositol polyphosphate 5-phosphatase type IV (INPP5E)
Homo sapiens — UniProt Q9NRR6
Data last refreshed: (UniProt release unknown)
Key facts
Phosphatidylinositol polyphosphate 5-phosphatase type IV (INPP5E) is a protein from Homo sapiens identified by UniProt accession Q9NRR6, 644 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.
- UniProt accession: Q9NRR6; gene symbol INPP5E.
- Organism: Homo sapiens.
- Length: 644 amino acids.
- Top disease associations (Open Targets): Joubert syndrome 1, Joubert syndrome and MORM syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphatidylinositol polyphosphate 5-phosphatase type IV |
|---|---|
| UniProt accession | Q9NRR6 |
| Gene | INPP5E |
| Organism | Homo sapiens |
| Length | 644 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (181)
Diseases linked to this target (Open Targets).
- Joubert syndrome 1 · score 0.84
- Joubert syndrome · score 0.75
- MORM syndrome · score 0.74
- Joubert syndrome and related disorders · score 0.51
- Retinal dystrophy · score 0.46
- Cone rod dystrophy · score 0.42
- genetic disorder · score 0.38
- Joubert syndrome with hepatic defect · score 0.37
- Joubert syndrome with ocular defect · score 0.37
- chronic lung disease · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRR6-F1 | alphafold | PREDICTED | 71.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRR6.
Amino-acid sequence (644 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with INPP5E?
The strongest Open Targets associations for INPP5E are Joubert syndrome 1, Joubert syndrome, MORM syndrome, Joubert syndrome and related disorders and Retinal dystrophy.
How long is the INPP5E protein?
The Homo sapiens INPP5E protein (UniProt Q9NRR6) is 644 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRR6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRR6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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