DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)
Homo sapiens — UniProt Q9NRW3
Data last refreshed: (UniProt release unknown)
Key facts
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) is a protein from Homo sapiens identified by UniProt accession Q9NRW3, 190 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.
- UniProt accession: Q9NRW3; gene symbol APOBEC3C.
- Organism: Homo sapiens.
- Length: 190 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hemoglobin A1 measurement and cutaneous melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA dC->dU-editing enzyme APOBEC-3C |
|---|---|
| UniProt accession | Q9NRW3 |
| Gene | APOBEC3C |
| Organism | Homo sapiens |
| Length | 190 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (105)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.24
- hemoglobin A1 measurement · score 0.21
- cutaneous melanoma · score 0.14
- breast neoplasm · score 0.12
- grey matter volume measurement · score 0.09
- immune deficiency, familial variable · score 0.08
- HER2 negative breast carcinoma · score 0.07
- immunodeficiency 35 · score 0.07
- Chronic mucocutaneous candidosis · score 0.07
- hyper-IgM syndrome type 2 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRW3-F1 | alphafold | PREDICTED | 91.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRW3.
Amino-acid sequence (190 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with APOBEC3C?
The strongest Open Targets associations for APOBEC3C are neurodegenerative disease, hemoglobin A1 measurement, cutaneous melanoma, breast neoplasm and grey matter volume measurement.
How long is the APOBEC3C protein?
The Homo sapiens APOBEC3C protein (UniProt Q9NRW3) is 190 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRW3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRW3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.