Dual specificity protein phosphatase 22 (DUSP22)
Homo sapiens — UniProt Q9NRW4
Data last refreshed: (UniProt release unknown)
Key facts
Dual specificity protein phosphatase 22 (DUSP22) is a protein from Homo sapiens identified by UniProt accession Q9NRW4, 184 residues long. MolForge cross-references it against 0 known binders and 304 disease associations.
- UniProt accession: Q9NRW4; gene symbol DUSP22.
- Organism: Homo sapiens.
- Length: 184 amino acids.
- Top disease associations (Open Targets): eosinophil count, neurodegenerative disease and eosinophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dual specificity protein phosphatase 22 |
|---|---|
| UniProt accession | Q9NRW4 |
| Gene | DUSP22 |
| Organism | Homo sapiens |
| Length | 184 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (304)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.37
- neurodegenerative disease · score 0.35
- eosinophil percentage of leukocytes · score 0.35
- total blood protein measurement · score 0.31
- hair color · score 0.27
- systemic lupus erythematosus · score 0.26
- lymphocyte count · score 0.24
- eosinophil percentage of granulocytes · score 0.24
- seasonal allergic rhinitis · score 0.24
- Eczematoid dermatitis · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRW4-F1 | alphafold | PREDICTED | 93.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRW4.
Amino-acid sequence (184 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DUSP22?
The strongest Open Targets associations for DUSP22 are eosinophil count, neurodegenerative disease, eosinophil percentage of leukocytes, total blood protein measurement and hair color.
How long is the DUSP22 protein?
The Homo sapiens DUSP22 protein (UniProt Q9NRW4) is 184 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRW4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRW4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.