Vacuolar protein sorting-associated protein 45 (VPS45)
Homo sapiens — UniProt Q9NRW7
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar protein sorting-associated protein 45 (VPS45) is a protein from Homo sapiens identified by UniProt accession Q9NRW7, 570 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.
- UniProt accession: Q9NRW7; gene symbol VPS45.
- Organism: Homo sapiens.
- Length: 570 amino acids.
- Top disease associations (Open Targets): congenital neutropenia-myelofibrosis-nephromegaly syndrome, Recurrent infections-myelofibrosis-nephromegaly syndrome and severe congenital neutropenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 45 |
|---|---|
| UniProt accession | Q9NRW7 |
| Gene | VPS45 |
| Organism | Homo sapiens |
| Length | 570 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (77)
Diseases linked to this target (Open Targets).
- congenital neutropenia-myelofibrosis-nephromegaly syndrome · score 0.73
- Recurrent infections-myelofibrosis-nephromegaly syndrome · score 0.68
- severe congenital neutropenia · score 0.59
- neurodegenerative disease · score 0.46
- COVID-19 · score 0.37
- schizophrenia · score 0.22
- bipolar disorder · score 0.20
- mathematical ability · score 0.19
- genetic disorder · score 0.19
- neutrophil count · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRW7-F1 | alphafold | PREDICTED | 90.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRW7.
Amino-acid sequence (570 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS45?
The strongest Open Targets associations for VPS45 are congenital neutropenia-myelofibrosis-nephromegaly syndrome, Recurrent infections-myelofibrosis-nephromegaly syndrome, severe congenital neutropenia, neurodegenerative disease and COVID-19.
How long is the VPS45 protein?
The Homo sapiens VPS45 protein (UniProt Q9NRW7) is 570 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRW7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRW7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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