RNA-binding protein PNO1 (PNO1)
Homo sapiens — UniProt Q9NRX1
Data last refreshed: (UniProt release unknown)
Key facts
RNA-binding protein PNO1 (PNO1) is a protein from Homo sapiens identified by UniProt accession Q9NRX1, 252 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.
- UniProt accession: Q9NRX1; gene symbol PNO1.
- Organism: Homo sapiens.
- Length: 252 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Alzheimer disease and multiple sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA-binding protein PNO1 |
|---|---|
| UniProt accession | Q9NRX1 |
| Gene | PNO1 |
| Organism | Homo sapiens |
| Length | 252 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (79)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- Alzheimer disease · score 0.34
- multiple sclerosis · score 0.34
- Parkinson disease · score 0.34
- lysosomal storage disease · score 0.34
- systolic blood pressure · score 0.32
- pulse pressure measurement · score 0.28
- cytokine measurement · score 0.19
- response to vaccine · score 0.19
- appendicular lean mass · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRX1-F1 | alphafold | PREDICTED | 77.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRX1.
Amino-acid sequence (252 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PNO1?
The strongest Open Targets associations for PNO1 are neurodegenerative disease, Alzheimer disease, multiple sclerosis, Parkinson disease and lysosomal storage disease.
How long is the PNO1 protein?
The Homo sapiens PNO1 protein (UniProt Q9NRX1) is 252 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRX1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRX1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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