Cytochrome c oxidase hypoxia associated subunit FA4L2 (COXFA4L2)
Homo sapiens — UniProt Q9NRX3
Data last refreshed: (UniProt release unknown)
Key facts
Cytochrome c oxidase hypoxia associated subunit FA4L2 (COXFA4L2) is a protein from Homo sapiens identified by UniProt accession Q9NRX3, 87 residues long. MolForge cross-references it against 0 known binders and 263 disease associations.
- UniProt accession: Q9NRX3; gene symbol COXFA4L2.
- Organism: Homo sapiens.
- Length: 87 amino acids.
- Top disease associations (Open Targets): type 2 diabetes mellitus, diabetes mellitus and polycystic ovary syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytochrome c oxidase hypoxia associated subunit FA4L2 |
|---|---|
| UniProt accession | Q9NRX3 |
| Gene | COXFA4L2 |
| Organism | Homo sapiens |
| Length | 87 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (263)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.61
- diabetes mellitus · score 0.60
- polycystic ovary syndrome · score 0.60
- type 1 diabetes mellitus · score 0.58
- gestational diabetes · score 0.58
- obesity · score 0.57
- schizophrenia · score 0.57
- prediabetes syndrome · score 0.56
- insulin resistance · score 0.55
- metabolic syndrome · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRX3-F1 | alphafold | PREDICTED | 84.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRX3.
Amino-acid sequence (87 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COXFA4L2?
The strongest Open Targets associations for COXFA4L2 are type 2 diabetes mellitus, diabetes mellitus, polycystic ovary syndrome, type 1 diabetes mellitus and gestational diabetes.
How long is the COXFA4L2 protein?
The Homo sapiens COXFA4L2 protein (UniProt Q9NRX3) is 87 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRX3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRX3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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