14 kDa phosphohistidine phosphatase (PHPT1)
Homo sapiens — UniProt Q9NRX4
Data last refreshed: (UniProt release unknown)
Key facts
14 kDa phosphohistidine phosphatase (PHPT1) is a protein from Homo sapiens identified by UniProt accession Q9NRX4, 125 residues long. MolForge cross-references it against 2 known binders and 79 disease associations.
- UniProt accession: Q9NRX4; gene symbol PHPT1.
- Organism: Homo sapiens.
- Length: 125 amino acids.
- Top disease associations (Open Targets): MODY, hyperinsulinism due to INSR deficiency and hyperinsulinism due to glucokinase deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 14 kDa phosphohistidine phosphatase |
|---|---|
| UniProt accession | Q9NRX4 |
| Gene | PHPT1 |
| Organism | Homo sapiens |
| Length | 125 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (79)
Diseases linked to this target (Open Targets).
- MODY · score 0.09
- hyperinsulinism due to INSR deficiency · score 0.07
- hyperinsulinism due to glucokinase deficiency · score 0.07
- type 2 diabetes mellitus · score 0.07
- exercise-induced hyperinsulinism · score 0.06
- type 1 diabetes mellitus · score 0.06
- diabetes mellitus, transient neonatal, 2 · score 0.06
- hyperinsulinism-hyperammonemia syndrome · score 0.06
- hyperinsulinemic hypoglycemia, familial, 2 · score 0.06
- hyperproinsulinemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRX4-F1 | alphafold | PREDICTED | 90.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRX4.
Amino-acid sequence (125 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHPT1?
The strongest Open Targets associations for PHPT1 are MODY, hyperinsulinism due to INSR deficiency, hyperinsulinism due to glucokinase deficiency, type 2 diabetes mellitus and exercise-induced hyperinsulinism.
How long is the PHPT1 protein?
The Homo sapiens PHPT1 protein (UniProt Q9NRX4) is 125 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRX4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRX4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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