1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4)
Homo sapiens — UniProt Q9NRZ5
Data last refreshed: (UniProt release unknown)
Key facts
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) is a protein from Homo sapiens identified by UniProt accession Q9NRZ5, 378 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q9NRZ5; gene symbol AGPAT4.
- Organism: Homo sapiens.
- Length: 378 amino acids.
- Top disease associations (Open Targets): lipoprotein A measurement, diastolic blood pressure and hip bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 1-acyl-sn-glycerol-3-phosphate acyltransferase delta |
|---|---|
| UniProt accession | Q9NRZ5 |
| Gene | AGPAT4 |
| Organism | Homo sapiens |
| Length | 378 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- lipoprotein A measurement · score 0.64
- diastolic blood pressure · score 0.38
- hip bone mineral density · score 0.34
- hip bone size · score 0.34
- apolipoprotein A 1 measurement · score 0.34
- fear of minor pain measurement · score 0.33
- systolic blood pressure · score 0.31
- breast adenocarcinoma · score 0.18
- lymphocyte count · score 0.07
- familial hypobetalipoproteinemia 2 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRZ5-F1 | alphafold | PREDICTED | 94.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRZ5.
Amino-acid sequence (378 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AGPAT4?
The strongest Open Targets associations for AGPAT4 are lipoprotein A measurement, diastolic blood pressure, hip bone mineral density, hip bone size and apolipoprotein A 1 measurement.
How long is the AGPAT4 protein?
The Homo sapiens AGPAT4 protein (UniProt Q9NRZ5) is 378 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRZ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRZ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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