1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3)
Homo sapiens — UniProt Q9NRZ7
Data last refreshed: (UniProt release unknown)
Key facts
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3) is a protein from Homo sapiens identified by UniProt accession Q9NRZ7, 376 residues long. MolForge cross-references it against 0 known binders and 224 disease associations.
- UniProt accession: Q9NRZ7; gene symbol AGPAT3.
- Organism: Homo sapiens.
- Length: 376 amino acids.
- Top disease associations (Open Targets): Intellectual disability, phosphatidylcholine measurement and glucose metabolism decline measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma |
|---|---|
| UniProt accession | Q9NRZ7 |
| Gene | AGPAT3 |
| Organism | Homo sapiens |
| Length | 376 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (224)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.38
- phosphatidylcholine measurement · score 0.26
- glucose metabolism decline measurement · score 0.20
- Neurodevelopmental disorder · score 0.18
- breast adenocarcinoma · score 0.18
- cystatin B measurement · score 0.17
- triacylglycerol 54:5 measurement · score 0.14
- blood protein measurement · score 0.14
- glomerular filtration rate · score 0.12
- azoospermia · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRZ7-F1 | alphafold | PREDICTED | 94.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRZ7.
Amino-acid sequence (376 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AGPAT3?
The strongest Open Targets associations for AGPAT3 are Intellectual disability, phosphatidylcholine measurement, glucose metabolism decline measurement, Neurodevelopmental disorder and breast adenocarcinoma.
How long is the AGPAT3 protein?
The Homo sapiens AGPAT3 protein (UniProt Q9NRZ7) is 376 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRZ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRZ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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