Lymphoid-specific helicase (HELLS)
Homo sapiens — UniProt Q9NRZ9
Data last refreshed: (UniProt release unknown)
Key facts
Lymphoid-specific helicase (HELLS) is a protein from Homo sapiens identified by UniProt accession Q9NRZ9, 838 residues long. MolForge cross-references it against 0 known binders and 238 disease associations.
- UniProt accession: Q9NRZ9; gene symbol HELLS.
- Organism: Homo sapiens.
- Length: 838 amino acids.
- Top disease associations (Open Targets): ICF syndrome, immunodeficiency-centromeric instability-facial anomalies syndrome and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lymphoid-specific helicase |
|---|---|
| UniProt accession | Q9NRZ9 |
| Gene | HELLS |
| Organism | Homo sapiens |
| Length | 838 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (238)
Diseases linked to this target (Open Targets).
- ICF syndrome · score 0.70
- immunodeficiency-centromeric instability-facial anomalies syndrome · score 0.46
- Red cell distribution width · score 0.43
- erythrocyte count · score 0.38
- mean reticulocyte volume · score 0.36
- neutrophil count · score 0.36
- mean corpuscular hemoglobin concentration · score 0.35
- neurodegenerative disease · score 0.32
- leukocyte count · score 0.29
- mean corpuscular hemoglobin · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NRZ9-F1 | alphafold | PREDICTED | 68.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NRZ9.
Amino-acid sequence (838 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HELLS?
The strongest Open Targets associations for HELLS are ICF syndrome, immunodeficiency-centromeric instability-facial anomalies syndrome, Red cell distribution width, erythrocyte count and mean reticulocyte volume.
How long is the HELLS protein?
The Homo sapiens HELLS protein (UniProt Q9NRZ9) is 838 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NRZ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NRZ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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