E3 ubiquitin-protein ligase Topors (TOPORS)
Homo sapiens — UniProt Q9NS56
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase Topors (TOPORS) is a protein from Homo sapiens identified by UniProt accession Q9NS56, 1045 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q9NS56; gene symbol TOPORS.
- Organism: Homo sapiens.
- Length: 1045 amino acids.
- Top disease associations (Open Targets): retinitis pigmentosa, Retinal dystrophy and autosomal dominant retinitis pigmentosa.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase Topors |
|---|---|
| UniProt accession | Q9NS56 |
| Gene | TOPORS |
| Organism | Homo sapiens |
| Length | 1045 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.71
- Retinal dystrophy · score 0.52
- autosomal dominant retinitis pigmentosa · score 0.41
- orofaciodigital syndrome type 6 · score 0.37
- inherited retinal dystrophy · score 0.37
- genetic disorder · score 0.19
- Pigmentary retinopathy · score 0.15
- Hypermetropia · score 0.12
- Blurred vision · score 0.12
- macular degeneration · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NS56-F1 | alphafold | PREDICTED | 49.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NS56.
Amino-acid sequence (1045 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TOPORS?
The strongest Open Targets associations for TOPORS are retinitis pigmentosa, Retinal dystrophy, autosomal dominant retinitis pigmentosa, orofaciodigital syndrome type 6 and inherited retinal dystrophy.
How long is the TOPORS protein?
The Homo sapiens TOPORS protein (UniProt Q9NS56) is 1045 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NS56 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NS56 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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