Gastrokine-1 (GKN1)

About Gastrokine-1

Gastrokine-1 (GKN1) is a protein from Homo sapiens identified by UniProt accession Q9NS71, 185 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Gastrokine-1
UniProt accession	Q9NS71
Gene	GKN1
Organism	Homo sapiens
Length	185 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

muscular dystrophy · score 0.29
gonorrhea · score 0.08
gastric carcinoma · score 0.07
body height · score 0.06
Obesity · score 0.05
gut microbiome measurement · score 0.05
intraocular pressure measurement · score 0.05
Barrett's esophagus · score 0.05
gastric non-cardia carcinoma · score 0.04
primary ovarian insufficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NS71-F1	alphafold	PREDICTED	82.69	—

Amino-acid sequence (185 residues)

MKFTIVFAGL LGVFLAPALA NYNINVNDDN NNAGSGQQSV SVNNEHNVAN VDNNNGWDSW NSIWDYGNGF AATRLFQKKT CIVHKMNKEV MPSIQSLDAL VKEKKLQGKG PGGPPPKGLM YSVNPNKVDD LSKFGKNIAN MCRGIPTYMA EEMQEASLFF YSGTCYTTSV LWIVDISFCG DTVEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards