Keratin, type II cuticular Hb4 (KRT84)
Homo sapiens — UniProt Q9NSB2
Data last refreshed: (UniProt release unknown)
Key facts
Keratin, type II cuticular Hb4 (KRT84) is a protein from Homo sapiens identified by UniProt accession Q9NSB2, 600 residues long. MolForge cross-references it against 0 known binders and 15 disease associations.
- UniProt accession: Q9NSB2; gene symbol KRT84.
- Organism: Homo sapiens.
- Length: 600 amino acids.
- Top disease associations (Open Targets): prostate adenocarcinoma, clear cell renal carcinoma and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin, type II cuticular Hb4 |
|---|---|
| UniProt accession | Q9NSB2 |
| Gene | KRT84 |
| Organism | Homo sapiens |
| Length | 600 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (15)
Diseases linked to this target (Open Targets).
- prostate adenocarcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- oral squamous cell carcinoma · score 0.07
- neoplasm · score 0.06
- hepatocellular carcinoma · score 0.01
- cancer · score 0.00
- respiratory distress syndrome in premature infants · score 0.00
- anxiety · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NSB2-F1 | alphafold | PREDICTED | 66.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSB2.
Amino-acid sequence (600 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRT84?
The strongest Open Targets associations for KRT84 are prostate adenocarcinoma, clear cell renal carcinoma, glioblastoma multiforme, breast adenocarcinoma and oral squamous cell carcinoma.
How long is the KRT84 protein?
The Homo sapiens KRT84 protein (UniProt Q9NSB2) is 600 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NSB2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NSB2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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