Keratin, type II cuticular Hb2 (KRT82)
Homo sapiens — UniProt Q9NSB4
Data last refreshed: (UniProt release unknown)
Key facts
Keratin, type II cuticular Hb2 (KRT82) is a protein from Homo sapiens identified by UniProt accession Q9NSB4, 513 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q9NSB4; gene symbol KRT82.
- Organism: Homo sapiens.
- Length: 513 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, head and neck squamous cell carcinoma and clear cell renal carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Keratin, type II cuticular Hb2 |
|---|---|
| UniProt accession | Q9NSB4 |
| Gene | KRT82 |
| Organism | Homo sapiens |
| Length | 513 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- head and neck squamous cell carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
- prostate adenocarcinoma · score 0.18
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- Aarskog-Scott syndrome, X-linked · score 0.02
- breast carcinoma · score 0.02
- alopecia areata · score 0.01
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NSB4-F1 | alphafold | PREDICTED | 71.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSB4.
Amino-acid sequence (513 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KRT82?
The strongest Open Targets associations for KRT82 are neurodegenerative disease, head and neck squamous cell carcinoma, clear cell renal carcinoma, prostate adenocarcinoma and ovarian cancer.
How long is the KRT82 protein?
The Homo sapiens KRT82 protein (UniProt Q9NSB4) is 513 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NSB4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NSB4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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