Homer protein homolog 2 (HOMER2)
Homo sapiens — UniProt Q9NSB8
Data last refreshed: (UniProt release unknown)
Key facts
Homer protein homolog 2 (HOMER2) is a protein from Homo sapiens identified by UniProt accession Q9NSB8, 354 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.
- UniProt accession: Q9NSB8; gene symbol HOMER2.
- Organism: Homo sapiens.
- Length: 354 amino acids.
- Top disease associations (Open Targets): autosomal dominant nonsyndromic hearing loss, deafness and vital capacity.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homer protein homolog 2 |
|---|---|
| UniProt accession | Q9NSB8 |
| Gene | HOMER2 |
| Organism | Homo sapiens |
| Length | 354 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (138)
Diseases linked to this target (Open Targets).
- autosomal dominant nonsyndromic hearing loss · score 0.56
- deafness · score 0.52
- vital capacity · score 0.22
- BMI-adjusted hip circumference · score 0.21
- forced expiratory volume · score 0.20
- high density lipoprotein cholesterol measurement · score 0.20
- genetic disorder · score 0.19
- nonsyndromic genetic hearing loss · score 0.18
- FEV/FVC ratio · score 0.18
- bipolar disorder · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NSB8-F1 | alphafold | PREDICTED | 88.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSB8.
Amino-acid sequence (354 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HOMER2?
The strongest Open Targets associations for HOMER2 are autosomal dominant nonsyndromic hearing loss, deafness, vital capacity, BMI-adjusted hip circumference and forced expiratory volume.
How long is the HOMER2 protein?
The Homo sapiens HOMER2 protein (UniProt Q9NSB8) is 354 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NSB8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NSB8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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