Sodium- and chloride-dependent GABA transporter 2 (SLC6A13)
Homo sapiens — UniProt Q9NSD5
Data last refreshed: (UniProt release unknown)
Key facts
Sodium- and chloride-dependent GABA transporter 2 (SLC6A13) is a protein from Homo sapiens identified by UniProt accession Q9NSD5, 602 residues long. MolForge cross-references it against 1 known binders and 54 disease associations.
- UniProt accession: Q9NSD5; gene symbol SLC6A13.
- Organism: Homo sapiens.
- Length: 602 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): glomerular filtration rate, creatinine measurement and serum metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium- and chloride-dependent GABA transporter 2 |
|---|---|
| UniProt accession | Q9NSD5 |
| Gene | SLC6A13 |
| Organism | Homo sapiens |
| Length | 602 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.46
- creatinine measurement · score 0.46
- serum metabolite measurement · score 0.45
- blood metabolite measurement · score 0.38
- urinary metabolite measurement · score 0.37
- beta-aminoisobutyric acid measurement · score 0.31
- chronic kidney disease · score 0.29
- Abnormality of refraction · score 0.27
- 3-aminoisobutyrate measurement · score 0.27
- 3-hydroxyisobutyrate measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NSD5-F1 | alphafold | PREDICTED | 88.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSD5.
Amino-acid sequence (602 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC6A13?
The strongest Open Targets associations for SLC6A13 are glomerular filtration rate, creatinine measurement, serum metabolite measurement, blood metabolite measurement and urinary metabolite measurement.
How long is the SLC6A13 protein?
The Homo sapiens SLC6A13 protein (UniProt Q9NSD5) is 602 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NSD5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NSD5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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