Relaxin-3 receptor 1 (RXFP3)

About Relaxin-3 receptor 1

Relaxin-3 receptor 1 (RXFP3) is a protein from Homo sapiens identified by UniProt accession Q9NSD7, 469 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.

Target properties

Protein name	Relaxin-3 receptor 1
UniProt accession	Q9NSD7
Gene	RXFP3
Organism	Homo sapiens
Length	469 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (113)

Diseases linked to this target (Open Targets).

ovarian cancer · score 0.25
cutaneous melanoma · score 0.21
lung adenocarcinoma · score 0.18
breast adenocarcinoma · score 0.17
head and neck squamous cell carcinoma · score 0.16
hair colour measurement · score 0.14
hair color · score 0.14
metabolite measurement · score 0.14
skin pigmentation · score 0.13
hair morphology measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NSD7-F1	alphafold	PREDICTED	72.98	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSD7.

Amino-acid sequence (469 residues)

MQMADAATIA TMNKAAGGDK LAELFSLVPD LLEAANTSGN ASLQLPDLWW ELGLELPDGA PPGHPPGSGG AESADTEARV RILISVVYWV VCALGLAGNL LVLYLMKSMQ GWRKSSINLF VTNLALTDFQ FVLTLPFWAV ENALDFKWPF GKAMCKIVSM VTSMNMYASV FFLTAMSVTR YHSVASALKS HRTRGHGRGD CCGRSLGDSC CFSAKALCVW IWALAALASL PSAIFSTTVK VMGEELCLVR FPDKLLGRDR QFWLGLYHSQ KVLLGFVLPL GIIILCYLLL VRFIADRRAA GTKGGAAVAG GRPTGASARR LSKVTKSVTI VVLSFFLCWL PNQALTTWSI LIKFNAVPFS QEYFLCQVYA FPVSVCLAHS NSCLNPVLYC LVRREFRKAL KSLLWRIASP SITSMRPFTA TTKPEHEDQG LQAPAPPHAA AEPDLLYYPP GVVVYSGGRY DLLPSSSAY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards