Phenylalanine--tRNA ligase beta subunit (FARSB)
Homo sapiens — UniProt Q9NSD9
Data last refreshed: (UniProt release unknown)
Key facts
Phenylalanine--tRNA ligase beta subunit (FARSB) is a protein from Homo sapiens identified by UniProt accession Q9NSD9, 589 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9NSD9; gene symbol FARSB.
- Organism: Homo sapiens.
- Length: 589 amino acids.
- Top disease associations (Open Targets): Rajab interstitial lung disease with brain calcifications 1, Rajab interstitial lung disease with brain calcifications and Cerebral calcification.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phenylalanine--tRNA ligase beta subunit |
|---|---|
| UniProt accession | Q9NSD9 |
| Gene | FARSB |
| Organism | Homo sapiens |
| Length | 589 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- Rajab interstitial lung disease with brain calcifications 1 · score 0.76
- Rajab interstitial lung disease with brain calcifications · score 0.61
- Cerebral calcification · score 0.50
- Interstitial pneumonitis · score 0.50
- cirrhosis of liver · score 0.50
- Vascular dilatation · score 0.50
- interstitial lung disease · score 0.42
- Microcephaly · score 0.42
- microcephaly · score 0.42
- Intellectual disability · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NSD9-F1 | alphafold | PREDICTED | 94.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSD9.
Amino-acid sequence (589 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FARSB?
The strongest Open Targets associations for FARSB are Rajab interstitial lung disease with brain calcifications 1, Rajab interstitial lung disease with brain calcifications, Cerebral calcification, Interstitial pneumonitis and cirrhosis of liver.
How long is the FARSB protein?
The Homo sapiens FARSB protein (UniProt Q9NSD9) is 589 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NSD9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NSD9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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