Gamma-1-syntrophin (SNTG1)
Homo sapiens — UniProt Q9NSN8
Data last refreshed: (UniProt release unknown)
Key facts
Gamma-1-syntrophin (SNTG1) is a protein from Homo sapiens identified by UniProt accession Q9NSN8, 517 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9NSN8; gene symbol SNTG1.
- Organism: Homo sapiens.
- Length: 517 amino acids.
- Top disease associations (Open Targets): age at first sexual intercourse measurement, antisocial behaviour measurement and attention deficit hyperactivity disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gamma-1-syntrophin |
|---|---|
| UniProt accession | Q9NSN8 |
| Gene | SNTG1 |
| Organism | Homo sapiens |
| Length | 517 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- age at first sexual intercourse measurement · score 0.33
- antisocial behaviour measurement · score 0.30
- attention deficit hyperactivity disorder · score 0.30
- substance abuse · score 0.30
- systolic blood pressure · score 0.29
- smoking status measurement · score 0.29
- neurodegenerative disease · score 0.29
- lysosomal storage disease · score 0.29
- Alzheimer disease · score 0.29
- Parkinson disease · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NSN8-F1 | alphafold | PREDICTED | 82.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSN8.
Amino-acid sequence (517 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNTG1?
The strongest Open Targets associations for SNTG1 are age at first sexual intercourse measurement, antisocial behaviour measurement, attention deficit hyperactivity disorder, substance abuse and systolic blood pressure.
How long is the SNTG1 protein?
The Homo sapiens SNTG1 protein (UniProt Q9NSN8) is 517 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NSN8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NSN8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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