Three-prime repair exonuclease 1 (TREX1)
Homo sapiens — UniProt Q9NSU2
Data last refreshed: (UniProt release unknown)
Key facts
Three-prime repair exonuclease 1 (TREX1) is a protein from Homo sapiens identified by UniProt accession Q9NSU2, 314 residues long. MolForge cross-references it against 0 known binders and 401 disease associations.
- UniProt accession: Q9NSU2; gene symbol TREX1.
- Organism: Homo sapiens.
- Length: 314 amino acids.
- Top disease associations (Open Targets): Aicardi-Goutieres syndrome 1, systemic lupus erythematosus and retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Three-prime repair exonuclease 1 |
|---|---|
| UniProt accession | Q9NSU2 |
| Gene | TREX1 |
| Organism | Homo sapiens |
| Length | 314 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (401)
Diseases linked to this target (Open Targets).
- Aicardi-Goutieres syndrome 1 · score 0.84
- systemic lupus erythematosus · score 0.77
- retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations · score 0.76
- Cerebroretinal vasculopathy · score 0.75
- Hereditary vascular retinopathy · score 0.75
- HERNS syndrome · score 0.75
- Aicardi-Goutières syndrome · score 0.72
- chilblain lupus 1 · score 0.70
- chilblain lupus · score 0.61
- Retinal vasculopathy and cerebral leukodystrophy · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NSU2-F1 | alphafold | PREDICTED | 80.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSU2.
Amino-acid sequence (314 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TREX1?
The strongest Open Targets associations for TREX1 are Aicardi-Goutieres syndrome 1, systemic lupus erythematosus, retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations, Cerebroretinal vasculopathy and Hereditary vascular retinopathy.
How long is the TREX1 protein?
The Homo sapiens TREX1 protein (UniProt Q9NSU2) is 314 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NSU2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NSU2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.