Protein diaphanous homolog 3 (DIAPH3)
Homo sapiens — UniProt Q9NSV4
Data last refreshed: (UniProt release unknown)
Key facts
Protein diaphanous homolog 3 (DIAPH3) is a protein from Homo sapiens identified by UniProt accession Q9NSV4, 1193 residues long. MolForge cross-references it against 0 known binders and 151 disease associations.
- UniProt accession: Q9NSV4; gene symbol DIAPH3.
- Organism: Homo sapiens.
- Length: 1193 amino acids.
- Top disease associations (Open Targets): autosomal dominant nonsyndromic hearing loss, self reported educational attainment and smoking status measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein diaphanous homolog 3 |
|---|---|
| UniProt accession | Q9NSV4 |
| Gene | DIAPH3 |
| Organism | Homo sapiens |
| Length | 1193 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (151)
Diseases linked to this target (Open Targets).
- autosomal dominant nonsyndromic hearing loss · score 0.57
- self reported educational attainment · score 0.41
- smoking status measurement · score 0.36
- age at first sexual intercourse measurement · score 0.34
- insomnia measurement · score 0.34
- cortical surface area measurement · score 0.34
- cortical thickness · score 0.34
- Hearing impairment · score 0.32
- lysosomal storage disease · score 0.30
- neurodegenerative disease · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NSV4-F1 | alphafold | PREDICTED | 71.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSV4.
Amino-acid sequence (1193 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DIAPH3?
The strongest Open Targets associations for DIAPH3 are autosomal dominant nonsyndromic hearing loss, self reported educational attainment, smoking status measurement, age at first sexual intercourse measurement and insomnia measurement.
How long is the DIAPH3 protein?
The Homo sapiens DIAPH3 protein (UniProt Q9NSV4) is 1193 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NSV4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NSV4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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