Nuclear receptor-binding protein 2 (NRBP2)
Homo sapiens — UniProt Q9NSY0
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear receptor-binding protein 2 (NRBP2) is a protein from Homo sapiens identified by UniProt accession Q9NSY0, 501 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q9NSY0; gene symbol NRBP2.
- Organism: Homo sapiens.
- Length: 501 amino acids.
- Target class: Nuclear receptor.
- Top disease associations (Open Targets): neoplasm, breast cancer and Mobius syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear receptor-binding protein 2 |
|---|---|
| UniProt accession | Q9NSY0 |
| Gene | NRBP2 |
| Organism | Homo sapiens |
| Length | 501 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Nuclear receptor (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.08
- breast cancer · score 0.08
- Mobius syndrome · score 0.08
- age at menarche · score 0.07
- hip circumference · score 0.06
- fat body mass · score 0.06
- Treacher-Collins syndrome · score 0.05
- low density lipoprotein cholesterol measurement · score 0.05
- mean platelet volume · score 0.04
- lean body mass · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NSY0-F1 | alphafold | PREDICTED | 79.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSY0.
Amino-acid sequence (501 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NRBP2?
The strongest Open Targets associations for NRBP2 are neoplasm, breast cancer, Mobius syndrome, age at menarche and hip circumference.
How long is the NRBP2 protein?
The Homo sapiens NRBP2 protein (UniProt Q9NSY0) is 501 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NSY0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NSY0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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