BMP-2-inducible protein kinase (BMP2K)
Homo sapiens — UniProt Q9NSY1
Data last refreshed: (UniProt release unknown)
Key facts
BMP-2-inducible protein kinase (BMP2K) is a protein from Homo sapiens identified by UniProt accession Q9NSY1, 1161 residues long. MolForge cross-references it against 22 known binders and 123 disease associations.
- UniProt accession: Q9NSY1; gene symbol BMP2K.
- Organism: Homo sapiens.
- Length: 1161 amino acids.
- Target class: Kinase.
- Approved drugs acting on it (DrugCentral): Baricitinib.
- Top disease associations (Open Targets): neurodegenerative disease, reticulocyte count and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BMP-2-inducible protein kinase |
|---|---|
| UniProt accession | Q9NSY1 |
| Gene | BMP2K |
| Organism | Homo sapiens |
| Length | 1161 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Kinase (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (123)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- reticulocyte count · score 0.49
- Red cell distribution width · score 0.49
- mean corpuscular volume · score 0.49
- Alzheimer disease · score 0.46
- lysosomal storage disease · score 0.46
- multiple sclerosis · score 0.46
- Parkinson disease · score 0.46
- hemoglobin measurement · score 0.46
- reticulocyte measurement · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NSY1-F1 | alphafold | PREDICTED | 55.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NSY1.
Amino-acid sequence (1161 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target BMP2K?
DrugCentral lists 1 approved drug whose mechanism of action is BMP2K: Baricitinib.
Which diseases are associated with BMP2K?
The strongest Open Targets associations for BMP2K are neurodegenerative disease, reticulocyte count, Red cell distribution width, mean corpuscular volume and Alzheimer disease.
How long is the BMP2K protein?
The Homo sapiens BMP2K protein (UniProt Q9NSY1) is 1161 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NSY1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NSY1 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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