NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)
Homo sapiens — UniProt Q9NTG7
Data last refreshed: (UniProt release unknown)
Key facts
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) is a protein from Homo sapiens identified by UniProt accession Q9NTG7, 399 residues long. MolForge cross-references it against 3 known binders and 543 disease associations.
- UniProt accession: Q9NTG7; gene symbol SIRT3.
- Organism: Homo sapiens.
- Length: 399 amino acids.
- Top disease associations (Open Targets): mean platelet volume, platelet count and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
|---|---|
| UniProt accession | Q9NTG7 |
| Gene | SIRT3 |
| Organism | Homo sapiens |
| Length | 399 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (543)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.26
- platelet count · score 0.24
- mean corpuscular volume · score 0.19
- lymphocyte count · score 0.19
- neurodegenerative disease · score 0.19
- HbA1c measurement · score 0.18
- bone density · score 0.15
- Red cell distribution width · score 0.14
- polyp of colon · score 0.13
- neoplasm · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NTG7-F1 | alphafold | PREDICTED | 75.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NTG7.
Amino-acid sequence (399 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIRT3?
The strongest Open Targets associations for SIRT3 are mean platelet volume, platelet count, mean corpuscular volume, lymphocyte count and neurodegenerative disease.
How long is the SIRT3 protein?
The Homo sapiens SIRT3 protein (UniProt Q9NTG7) is 399 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NTG7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NTG7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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