Sister chromatid cohesion protein PDS5 homolog B (PDS5B)
Homo sapiens — UniProt Q9NTI5
Data last refreshed: (UniProt release unknown)
Key facts
Sister chromatid cohesion protein PDS5 homolog B (PDS5B) is a protein from Homo sapiens identified by UniProt accession Q9NTI5, 1447 residues long. MolForge cross-references it against 0 known binders and 406 disease associations.
- UniProt accession: Q9NTI5; gene symbol PDS5B.
- Organism: Homo sapiens.
- Length: 1447 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean corpuscular volume and body fat percentage.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sister chromatid cohesion protein PDS5 homolog B |
|---|---|
| UniProt accession | Q9NTI5 |
| Gene | PDS5B |
| Organism | Homo sapiens |
| Length | 1447 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (406)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- mean corpuscular volume · score 0.48
- body fat percentage · score 0.48
- body mass index · score 0.48
- platelet count · score 0.45
- body height · score 0.45
- serum alanine aminotransferase measurement · score 0.45
- mean platelet volume · score 0.45
- mean corpuscular hemoglobin · score 0.42
- mean corpuscular hemoglobin concentration · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NTI5-F1 | alphafold | PREDICTED | 80.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NTI5.
Amino-acid sequence (1447 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PDS5B?
The strongest Open Targets associations for PDS5B are neurodegenerative disease, mean corpuscular volume, body fat percentage, body mass index and platelet count.
How long is the PDS5B protein?
The Homo sapiens PDS5B protein (UniProt Q9NTI5) is 1447 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NTI5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NTI5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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