Phosphatidylinositol-3-phosphatase SAC1 (SACM1L)
Homo sapiens — UniProt Q9NTJ5
Data last refreshed: (UniProt release unknown)
Key facts
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) is a protein from Homo sapiens identified by UniProt accession Q9NTJ5, 587 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.
- UniProt accession: Q9NTJ5; gene symbol SACM1L.
- Organism: Homo sapiens.
- Length: 587 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, cortical thickness and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphatidylinositol-3-phosphatase SAC1 |
|---|---|
| UniProt accession | Q9NTJ5 |
| Gene | SACM1L |
| Organism | Homo sapiens |
| Length | 587 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- cortical thickness · score 0.23
- breast adenocarcinoma · score 0.23
- cutaneous melanoma · score 0.18
- neuroinflammatory disorder · score 0.18
- serum metabolite measurement · score 0.16
- squamous cell lung carcinoma · score 0.12
- cortical surface area measurement · score 0.12
- head and neck squamous cell carcinoma · score 0.11
- neuroimaging measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NTJ5-F1 | alphafold | PREDICTED | 90.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NTJ5.
Amino-acid sequence (587 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SACM1L?
The strongest Open Targets associations for SACM1L are neurodegenerative disease, cortical thickness, breast adenocarcinoma, cutaneous melanoma and neuroinflammatory disorder.
How long is the SACM1L protein?
The Homo sapiens SACM1L protein (UniProt Q9NTJ5) is 587 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NTJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NTJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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