About Phosphatidylinositol-3-phosphatase SAC1
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) is a protein
from Homo sapiens identified by UniProt accession
Q9NTJ5, 587 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Phosphatidylinositol-3-phosphatase SAC1 |
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| UniProt accession | Q9NTJ5 |
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| Gene | SACM1L |
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| Organism | Homo sapiens |
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| Length | 587 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- cortical thickness · score 0.23
- breast adenocarcinoma · score 0.23
- cutaneous melanoma · score 0.18
- neuroinflammatory disorder · score 0.18
- serum metabolite measurement · score 0.16
- squamous cell lung carcinoma · score 0.12
- cortical surface area measurement · score 0.12
- head and neck squamous cell carcinoma · score 0.11
- neuroimaging measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9NTJ5-F1 | alphafold | PREDICTED | 90.77 | — |
Amino-acid sequence (587 residues)
MATAAYEQLK LHITPEKFYV EACDDGADDV LTIDRVSTEV TLAVKKDVPP SAVTRPIFGI LGTIHLVAGN YLIVITKKIK VGEFFSHVVW KATDFDVLSY KKTMLHLTDI QLQDNKTFLA MLNHVLNVDG FYFSTTYDLT HTLQRLSNTS PEFQEMSLLE RADQRFVWNG HLLRELSAQP EVHRFALPVL HGFITMHSCS INGKYFDWIL ISRRSCFRAG VRYYVRGIDS EGHAANFVET EQIVHYNGSK ASFVQTRGSI PVFWSQRPNL KYKPLPQISK VANHMDGFQR HFDSQVIIYG KQVIINLINQ KGSEKPLEQT FATMVSSLGS GMMRYIAFDF HKECKNMRWD RLSILLDQVA EMQDELSYFL VDSAGQVVAN QEGVFRSNCM DCLDRTNVIQ SLLARRSLQA QLQRLGVLHV GQKLEEQDEF EKIYKNAWAD NANACAKQYA GTGALKTDFT RTGKRTHLGL IMDGWNSMIR YYKNNFSDGF RQDSIDLFLG NYSVDELESH SPLSVPRDWK FLALPIIMVV AFSMCIICLL MAGDTWTETL AYVLFWGVAS IGTFFIILYN GKDFVDAPRL VQKEKID
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