Gap junction beta-4 protein (GJB4)
Homo sapiens — UniProt Q9NTQ9
Data last refreshed: (UniProt release unknown)
Key facts
Gap junction beta-4 protein (GJB4) is a protein from Homo sapiens identified by UniProt accession Q9NTQ9, 266 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q9NTQ9; gene symbol GJB4.
- Organism: Homo sapiens.
- Length: 266 amino acids.
- Top disease associations (Open Targets): erythrokeratodermia variabilis, genetic disorder and daytime rest measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gap junction beta-4 protein |
|---|---|
| UniProt accession | Q9NTQ9 |
| Gene | GJB4 |
| Organism | Homo sapiens |
| Length | 266 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- erythrokeratodermia variabilis · score 0.70
- genetic disorder · score 0.19
- daytime rest measurement · score 0.15
- hip bone size · score 0.14
- lung adenocarcinoma · score 0.14
- autosomal dominant nonsyndromic hearing loss 3A · score 0.12
- deafness · score 0.12
- hearing loss, autosomal recessive · score 0.12
- PHF-tau measurement · score 0.10
- gonorrhea · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NTQ9-F1 | alphafold | PREDICTED | 78.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NTQ9.
Amino-acid sequence (266 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GJB4?
The strongest Open Targets associations for GJB4 are erythrokeratodermia variabilis, genetic disorder, daytime rest measurement, hip bone size and lung adenocarcinoma.
How long is the GJB4 protein?
The Homo sapiens GJB4 protein (UniProt Q9NTQ9) is 266 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NTQ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NTQ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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