Cerebral cavernous malformations 2 protein-like (CCM2L)
Homo sapiens — UniProt Q9NUG4
Data last refreshed: (UniProt release unknown)
Key facts
Cerebral cavernous malformations 2 protein-like (CCM2L) is a protein from Homo sapiens identified by UniProt accession Q9NUG4, 571 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q9NUG4; gene symbol CCM2L.
- Organism: Homo sapiens.
- Length: 571 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, drug use measurement and monocyte percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cerebral cavernous malformations 2 protein-like |
|---|---|
| UniProt accession | Q9NUG4 |
| Gene | CCM2L |
| Organism | Homo sapiens |
| Length | 571 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- drug use measurement · score 0.22
- monocyte percentage of leukocytes · score 0.04
- non-small cell lung carcinoma · score 0.02
- cortical surface area measurement · score 0.02
- alkaline phosphatase measurement · score 0.02
- reticulocyte measurement · score 0.02
- lung adenocarcinoma · score 0.01
- cerebral cavernous malformation · score 0.01
- uterine leiomyosarcoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUG4-F1 | alphafold | PREDICTED | 58.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUG4.
Amino-acid sequence (571 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CCM2L?
The strongest Open Targets associations for CCM2L are neurodegenerative disease, drug use measurement, monocyte percentage of leukocytes, non-small cell lung carcinoma and cortical surface area measurement.
How long is the CCM2L protein?
The Homo sapiens CCM2L protein (UniProt Q9NUG4) is 571 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUG4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUG4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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