Transmembrane protein 14B (TMEM14B)
Homo sapiens — UniProt Q9NUH8
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 14B (TMEM14B) is a protein from Homo sapiens identified by UniProt accession Q9NUH8, 114 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.
- UniProt accession: Q9NUH8; gene symbol TMEM14B.
- Organism: Homo sapiens.
- Length: 114 amino acids.
- Top disease associations (Open Targets): hyperparathyroidism, parathyroid disease and benign neoplasm of parathyroid gland.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 14B |
|---|---|
| UniProt accession | Q9NUH8 |
| Gene | TMEM14B |
| Organism | Homo sapiens |
| Length | 114 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- hyperparathyroidism · score 0.10
- parathyroid disease · score 0.08
- benign neoplasm of parathyroid gland · score 0.07
- Blackfan-Diamond anemia · score 0.07
- hemoglobin D disease · score 0.05
- dominant beta-thalassemia · score 0.05
- hemoglobin H disease · score 0.04
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.04
- hemoglobin E disease · score 0.04
- dehydrated hereditary stomatocytosis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUH8-F1 | alphafold | PREDICTED | 59.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUH8.
Amino-acid sequence (114 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM14B?
The strongest Open Targets associations for TMEM14B are hyperparathyroidism, parathyroid disease, benign neoplasm of parathyroid gland, Blackfan-Diamond anemia and hemoglobin D disease.
How long is the TMEM14B protein?
The Homo sapiens TMEM14B protein (UniProt Q9NUH8) is 114 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUH8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUH8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.