Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL)
Homo sapiens — UniProt Q9NUL5
Data last refreshed: (UniProt release unknown)
Key facts
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL) is a protein from Homo sapiens identified by UniProt accession Q9NUL5, 291 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q9NUL5; gene symbol SHFL.
- Organism: Homo sapiens.
- Length: 291 amino acids.
- Top disease associations (Open Targets): Genetic visceral malformation of the liver, biliary tract, pancreas or spleen, body height and ICAM-1 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Shiftless antiviral inhibitor of ribosomal frameshifting protein |
|---|---|
| UniProt accession | Q9NUL5 |
| Gene | SHFL |
| Organism | Homo sapiens |
| Length | 291 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- Genetic visceral malformation of the liver, biliary tract, pancreas or spleen · score 0.04
- body height · score 0.04
- ICAM-1 measurement · score 0.04
- Zika virus infectious disease · score 0.04
- Crigler-Najjar syndrome type 2 · score 0.04
- infection · score 0.03
- infect · score 0.03
- narcolepsy-cataplexy syndrome · score 0.03
- familial visceral myopathy · score 0.03
- serum gamma-glutamyl transferase measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUL5-F1 | alphafold | PREDICTED | 88.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUL5.
Amino-acid sequence (291 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHFL?
The strongest Open Targets associations for SHFL are Genetic visceral malformation of the liver, biliary tract, pancreas or spleen, body height, ICAM-1 measurement, Zika virus infectious disease and Crigler-Najjar syndrome type 2.
How long is the SHFL protein?
The Homo sapiens SHFL protein (UniProt Q9NUL5) is 291 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUL5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUL5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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