Alkaline ceramidase 3 (ACER3)
Homo sapiens — UniProt Q9NUN7
Data last refreshed: (UniProt release unknown)
Key facts
Alkaline ceramidase 3 (ACER3) is a protein from Homo sapiens identified by UniProt accession Q9NUN7, 267 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q9NUN7; gene symbol ACER3.
- Organism: Homo sapiens.
- Length: 267 amino acids.
- Top disease associations (Open Targets): alkaline ceramidase 3 deficiency, leukodystrophy and verbal-numerical reasoning measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alkaline ceramidase 3 |
|---|---|
| UniProt accession | Q9NUN7 |
| Gene | ACER3 |
| Organism | Homo sapiens |
| Length | 267 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- alkaline ceramidase 3 deficiency · score 0.73
- leukodystrophy · score 0.37
- verbal-numerical reasoning measurement · score 0.17
- non-alcoholic steatohepatitis · score 0.08
- colitis · score 0.07
- hepatocellular carcinoma · score 0.06
- body fat percentage · score 0.04
- Platelet-activating factor acetylhydrolase deficiency · score 0.03
- acute myeloid leukemia · score 0.03
- vitamin D measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUN7-F1 | alphafold | PREDICTED | 93.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUN7.
Amino-acid sequence (267 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACER3?
The strongest Open Targets associations for ACER3 are alkaline ceramidase 3 deficiency, leukodystrophy, verbal-numerical reasoning measurement, non-alcoholic steatohepatitis and colitis.
How long is the ACER3 protein?
The Homo sapiens ACER3 protein (UniProt Q9NUN7) is 267 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUN7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUN7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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