1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5)
Homo sapiens — UniProt Q9NUQ2
Data last refreshed: (UniProt release unknown)
Key facts
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) is a protein from Homo sapiens identified by UniProt accession Q9NUQ2, 364 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q9NUQ2; gene symbol AGPAT5.
- Organism: Homo sapiens.
- Length: 364 amino acids.
- Top disease associations (Open Targets): low density lipoprotein cholesterol measurement, serum alanine aminotransferase measurement and alkaline phosphatase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon |
|---|---|
| UniProt accession | Q9NUQ2 |
| Gene | AGPAT5 |
| Organism | Homo sapiens |
| Length | 364 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.30
- serum alanine aminotransferase measurement · score 0.29
- alkaline phosphatase measurement · score 0.28
- total cholesterol measurement · score 0.26
- high density lipoprotein cholesterol measurement · score 0.25
- alcohol drinking · score 0.23
- alcohol consumption measurement · score 0.23
- apolipoprotein A 1 measurement · score 0.21
- breast adenocarcinoma · score 0.18
- gut microbiome measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUQ2-F1 | alphafold | PREDICTED | 94.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUQ2.
Amino-acid sequence (364 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AGPAT5?
The strongest Open Targets associations for AGPAT5 are low density lipoprotein cholesterol measurement, serum alanine aminotransferase measurement, alkaline phosphatase measurement, total cholesterol measurement and high density lipoprotein cholesterol measurement.
How long is the AGPAT5 protein?
The Homo sapiens AGPAT5 protein (UniProt Q9NUQ2) is 364 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUQ2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUQ2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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