CYFIP-related Rac1 interactor B (CYRIB)
Homo sapiens — UniProt Q9NUQ9
Data last refreshed: (UniProt release unknown)
Key facts
CYFIP-related Rac1 interactor B (CYRIB) is a protein from Homo sapiens identified by UniProt accession Q9NUQ9, 324 residues long. MolForge cross-references it against 0 known binders and 169 disease associations.
- UniProt accession: Q9NUQ9; gene symbol CYRIB.
- Organism: Homo sapiens.
- Length: 324 amino acids.
- Top disease associations (Open Targets): lymphocyte count, Red cell distribution width and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CYFIP-related Rac1 interactor B |
|---|---|
| UniProt accession | Q9NUQ9 |
| Gene | CYRIB |
| Organism | Homo sapiens |
| Length | 324 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (169)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.45
- Red cell distribution width · score 0.45
- platelet count · score 0.44
- mean corpuscular hemoglobin concentration · score 0.44
- mean corpuscular volume · score 0.43
- bilirubin measurement · score 0.42
- self reported educational attainment · score 0.41
- reticulocyte count · score 0.41
- lymphocyte percentage of leukocytes · score 0.38
- mean reticulocyte volume · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUQ9-F1 | alphafold | PREDICTED | 91.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUQ9.
Amino-acid sequence (324 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CYRIB?
The strongest Open Targets associations for CYRIB are lymphocyte count, Red cell distribution width, platelet count, mean corpuscular hemoglobin concentration and mean corpuscular volume.
How long is the CYRIB protein?
The Homo sapiens CYRIB protein (UniProt Q9NUQ9) is 324 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUQ9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUQ9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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