Transmembrane protein 74B (TMEM74B)
Homo sapiens — UniProt Q9NUR3
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 74B (TMEM74B) is a protein from Homo sapiens identified by UniProt accession Q9NUR3, 256 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: Q9NUR3; gene symbol TMEM74B.
- Organism: Homo sapiens.
- Length: 256 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, visual perception measurement and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 74B |
|---|---|
| UniProt accession | Q9NUR3 |
| Gene | TMEM74B |
| Organism | Homo sapiens |
| Length | 256 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- visual perception measurement · score 0.11
- mean platelet volume · score 0.03
- blood protein measurement · score 0.03
- non-small cell lung carcinoma · score 0.01
- neoplasm · score 0.00
- breast cancer · score 0.00
- prostate carcinoma · score 0.00
- diabetes mellitus · score 0.00
- interstitial lung disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUR3-F1 | alphafold | PREDICTED | 56.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUR3.
Amino-acid sequence (256 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM74B?
The strongest Open Targets associations for TMEM74B are neurodegenerative disease, visual perception measurement, mean platelet volume, blood protein measurement and non-small cell lung carcinoma.
How long is the TMEM74B protein?
The Homo sapiens TMEM74B protein (UniProt Q9NUR3) is 256 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUR3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUR3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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