Inactive ubiquitin thioesterase OTULINL (OTULINL)
Homo sapiens — UniProt Q9NUU6
Data last refreshed: (UniProt release unknown)
Key facts
Inactive ubiquitin thioesterase OTULINL (OTULINL) is a protein from Homo sapiens identified by UniProt accession Q9NUU6, 356 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q9NUU6; gene symbol OTULINL.
- Organism: Homo sapiens.
- Length: 356 amino acids.
- Top disease associations (Open Targets): asthma, eosinophil count and childhood onset asthma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inactive ubiquitin thioesterase OTULINL |
|---|---|
| UniProt accession | Q9NUU6 |
| Gene | OTULINL |
| Organism | Homo sapiens |
| Length | 356 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- asthma · score 0.52
- eosinophil count · score 0.51
- childhood onset asthma · score 0.46
- eosinophil percentage of leukocytes · score 0.42
- atopic eczema · score 0.42
- Inhalant adrenergic use measurement · score 0.39
- Eczematoid dermatitis · score 0.36
- atopic asthma · score 0.33
- respiratory system disease · score 0.33
- PHF-tau measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUU6-F1 | alphafold | PREDICTED | 88.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUU6.
Amino-acid sequence (356 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OTULINL?
The strongest Open Targets associations for OTULINL are asthma, eosinophil count, childhood onset asthma, eosinophil percentage of leukocytes and atopic eczema.
How long is the OTULINL protein?
The Homo sapiens OTULINL protein (UniProt Q9NUU6) is 356 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUU6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUU6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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