Serine palmitoyltransferase 3 (SPTLC3)
Homo sapiens — UniProt Q9NUV7
Data last refreshed: (UniProt release unknown)
Key facts
Serine palmitoyltransferase 3 (SPTLC3) is a protein from Homo sapiens identified by UniProt accession Q9NUV7, 552 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.
- UniProt accession: Q9NUV7; gene symbol SPTLC3.
- Organism: Homo sapiens.
- Length: 552 amino acids.
- Top disease associations (Open Targets): sphingomyelin measurement, genotoxic compound exposure measurement and phosphatidylcholine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine palmitoyltransferase 3 |
|---|---|
| UniProt accession | Q9NUV7 |
| Gene | SPTLC3 |
| Organism | Homo sapiens |
| Length | 552 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (170)
Diseases linked to this target (Open Targets).
- sphingomyelin measurement · score 0.54
- genotoxic compound exposure measurement · score 0.50
- phosphatidylcholine measurement · score 0.50
- ceramide measurement · score 0.48
- serum metabolite measurement · score 0.47
- sphingolipid measurement · score 0.46
- low density lipoprotein cholesterol measurement · score 0.44
- blood metabolite measurement · score 0.43
- triglyceride measurement · score 0.43
- serum alanine aminotransferase measurement · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUV7-F1 | alphafold | PREDICTED | 87.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUV7.
Amino-acid sequence (552 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPTLC3?
The strongest Open Targets associations for SPTLC3 are sphingomyelin measurement, genotoxic compound exposure measurement, phosphatidylcholine measurement, ceramide measurement and serum metabolite measurement.
How long is the SPTLC3 protein?
The Homo sapiens SPTLC3 protein (UniProt Q9NUV7) is 552 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUV7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUV7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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