Tyrosyl-DNA phosphodiesterase 1 (TDP1)
Homo sapiens — UniProt Q9NUW8
Data last refreshed: (UniProt release unknown)
Key facts
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a protein from Homo sapiens identified by UniProt accession Q9NUW8, 608 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.
- UniProt accession: Q9NUW8; gene symbol TDP1.
- Organism: Homo sapiens.
- Length: 608 amino acids.
- Top disease associations (Open Targets): spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1, Spinocerebellar ataxia type 1 with axonal neuropathy and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tyrosyl-DNA phosphodiesterase 1 |
|---|---|
| UniProt accession | Q9NUW8 |
| Gene | TDP1 |
| Organism | Homo sapiens |
| Length | 608 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (120)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 · score 0.56
- Spinocerebellar ataxia type 1 with axonal neuropathy · score 0.46
- neurodegenerative disease · score 0.36
- Uveal Melanoma · score 0.28
- Epithelioid Cell Uveal Melanoma · score 0.28
- breast adenocarcinoma · score 0.23
- ovarian cancer · score 0.18
- drug use measurement · score 0.15
- autosomal recessive cerebellar ataxia · score 0.12
- lung adenocarcinoma · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NUW8-F1 | alphafold | PREDICTED | 80.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NUW8.
Amino-acid sequence (608 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TDP1?
The strongest Open Targets associations for TDP1 are spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1, Spinocerebellar ataxia type 1 with axonal neuropathy, neurodegenerative disease, Uveal Melanoma and Epithelioid Cell Uveal Melanoma.
How long is the TDP1 protein?
The Homo sapiens TDP1 protein (UniProt Q9NUW8) is 608 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NUW8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NUW8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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